7 8 KSI-102 and KSI-103: Engineered to inhibit TNF- α /IL-6 and IL-1/IL-6 through dual cytokine targeting IL-1 Trap α IL-6 KSI-103 (IL-1 trap / α IL-6 bispecific) α TNF α TNF- α α IL-6 KSI-102 ( α TNF- α / α IL-6 bispecific) TNF- α IL-6 Dual target binding with pM affinity IL-1 trap mimics native heterodimeric receptor and can bind to IL-1 α or IL-1 β IL-1 α / β IL-6 Dual target binding with pM affinity